Allosteric Signalling and a Nuclear Exit Strategy: Binding of UL25/UL17 Heterodimers to DNA-filled HSV-1 Capsids

UL25 and UL17 are two essential minor capsid proteins of HSV-1, implicated in DNA packaging and capsid maturation. We used cryo-electron microscopy to examine their binding to capsids, whose architecture observes T=16 icosahedral geometry. C-capsids (mature DNA-filled capsids) have an elongated two-...

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Bibliographic Details
Main Authors: Trus, Benes L., Newcomb, William W., Cheng, Naiqian, Cardone, Giovanni, Marekov, Lyuben, Homa, Fred L., Brown, Jay C., Steven, Alasdair C.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1945812/
https://ncbi.nlm.nih.gov/pubmed/17531807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.04.010
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