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Characterization of individual polynucleotide molecules using a membrane channel

We show that an electric field can drive single-stranded RNA and DNA molecules through a 2.6-nm diameter ion channel in a lipid bilayer membrane. Because the channel diameter can accommodate only a single strand of RNA or DNA, each polymer traverses the membrane as an extended chain that partially b...

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Detalhes bibliográficos
Main Authors: Kasianowicz, John J., Brandin, Eric, Branton, Daniel, Deamer, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19421/
https://ncbi.nlm.nih.gov/pubmed/8943010
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