Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways

The Th2 cytokines interleukin (IL)-4 and IL-13 and chemokine monocyte chemoattractant protein-1 (MCP-1) are significantly involved in bronchial hyperreactivity (BHR) and remodelling in allergic asthma. Although IL-4 and IL-13 can regulate a number of chemokines from bronchial epithelium, their regul...

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Detalhes bibliográficos
Main Authors: Ip, W K, Wong, C K, Lam, C W K
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Basic Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1942012/
https://ncbi.nlm.nih.gov/pubmed/16792687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2006.03085.x
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