Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743

Adducts induced by the antitumor alkylator ecteinascidin 743 (ET-743, Yondelis, trabectedin) represent a unique challenge to the DNA repair machinery because no pathway examined to date is able to remove the ET adducts, whereas cells deficient in nucleotide excision repair show increased resistance....

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Bibliographische Detailangaben
Hauptverfasser: Soares, Daniele Grazziotin, Escargueil, Alexandre E., Poindessous, Virginie, Sarasin, Alain, de Gramont, Aimery, Bonatto, Diego, Henriques, João Antonio Pêgas, Larsen, Annette K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941813/
https://ncbi.nlm.nih.gov/pubmed/17656556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609877104
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