Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743

Adducts induced by the antitumor alkylator ecteinascidin 743 (ET-743, Yondelis, trabectedin) represent a unique challenge to the DNA repair machinery because no pathway examined to date is able to remove the ET adducts, whereas cells deficient in nucleotide excision repair show increased resistance....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Soares, Daniele Grazziotin, Escargueil, Alexandre E., Poindessous, Virginie, Sarasin, Alain, de Gramont, Aimery, Bonatto, Diego, Henriques, João Antonio Pêgas, Larsen, Annette K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941813/
https://ncbi.nlm.nih.gov/pubmed/17656556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609877104
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