Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

Shigella infection, the cause of bacillary dysentery, induces caspase-1 activation and cell death in macrophages, but the precise mechanisms of this activation remain poorly understood. We demonstrate here that caspase-1 activation and IL-1β processing induced by Shigella are mediated through Ipaf,...

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Bibliographic Details
Main Authors: Suzuki, Toshihiko, Franchi, Luigi, Toma, Claudia, Ashida, Hiroshi, Ogawa, Michinaga, Yoshikawa, Yuko, Mimuro, Hitomi, Inohara, Naohiro, Sasakawa, Chihiro, Nuñez, Gabriel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941748/
https://ncbi.nlm.nih.gov/pubmed/17696608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030111
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