A Free Energy Cascade with Locks Drives Assembly and Maturation of Bacteriophage HK97 Capsid.

We investigated the thermodynamic basis of HK97 assembly by scanning calorimetry and cryo-electron microscopy. This pathway involves self-assembly of hexamers and pentamers of the precursor capsid protein gp5 into procapsids; proteolysis of their N-terminal Δdomains; expansion - a major conformation...

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Hauptverfasser: Ross, Philip D., Conway, James F., Cheng, Naiqian, Dierkes, Lindsay, Firek, Brian A., Hendrix, Roger W., Steven, Alasdair C., Duda, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941702/
https://ncbi.nlm.nih.gov/pubmed/17007875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.08.048
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