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Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
Arsenic trioxide (ATO) is an effective cancer therapeutic drug for acute promyelocytic leukemia and has potential anticancer activity against a wide range of solid tumors. ATO exerts its effect mainly through elevated oxidative stress, but the exact molecular mechanism remains elusive. The thioredox...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2007
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1940330/ https://ncbi.nlm.nih.gov/pubmed/17640917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701549104 |
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