Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer initiating insults such as genotoxic stress. In this report, we demonstrate that microRNAs (miRNAs) are important components of the p53 transcriptional network. Global miRNA expression analyses identified a c...

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Autors principals: Chang, Tsung-Cheng, Wentzel, Erik A., Kent, Oliver A., Ramachandran, Kalyani, Mullendore, Michael, Lee, Kwang Hyuck, Feldmann, Georg, Yamakuchi, Munekazu, Ferlito, Marcella, Lowenstein, Charles J., Arking, Dan E., Beer, Michael A., Maitra, Anirban, Mendell, Joshua T.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939978/
https://ncbi.nlm.nih.gov/pubmed/17540599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.05.010
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