ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

BACKGROUND: The generation of the amyloid-β peptide (Aβ) through the proteolytic processing of the amyloid precursor protein (APP) is a central event in the pathogenesis of Alzheimer's disease (AD). Recent studies highlight APP endocytosis and localization to lipid rafts as important events fav...

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Detalhes bibliográficos
Main Authors: Fuentealba, Rodrigo A, Barría, Maria Ines, Lee, Jiyeon, Cam, Judy, Araya, Claudia, Escudero, Claudia A, Inestrosa, Nibaldo C, Bronfman, Francisca C, Bu, Guojun, Marzolo, Maria-Paz
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939850/
https://ncbi.nlm.nih.gov/pubmed/17620134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-14
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