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Protein Kinase Cα (PKCα) Acts Upstream of PKCθ To Activate IκB Kinase and NF-κB in T Lymphocytes

NF-κB is an ubiquitous transcription factor that is a key in the regulation of the immune response and inflammation. T-cell receptor (TCR) cross-linking leads to NF-κB activation, an IκB kinase (IKK)-dependent process. However, the upstream kinases that regulate IKK activity following TCR activation...

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Autors principals: Trushin, Sergey A., Pennington, Kevin N., Carmona, Eva M., Asin, Susana, Savoy, Doris N., Billadeau, Daniel D., Paya, Carlos V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC193945/
https://ncbi.nlm.nih.gov/pubmed/12972622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.19.7068-7081.2003
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