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Phosphorylation of the Carboxyl-Terminal Transactivation Domain of c-Fos by Extracellular Signal-Regulated Kinase Mediates the Transcriptional Activation of AP-1 and Cellular Transformation Induced by Platelet-Derived Growth Factor

Polypeptide growth factors, such as platelet-derived growth factor (PDGF), promote the reinitiation of DNA synthesis and cell growth through multiple intracellular signaling pathways that converge in the nucleus to regulate the activity of transcription factors, thereby controlling the expression of...

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Detalhes bibliográficos
Main Authors: Monje, Paula, Marinissen, Maria Julia, Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193921/
https://ncbi.nlm.nih.gov/pubmed/12972619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.19.7030-7043.2003
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