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Validation of Serological Correlate of Protection for Meningococcal C Conjugate Vaccine by Using Efficacy Estimates from Postlicensure Surveillance in England

Meningococcal C conjugate (MCC) vaccines were licensed on the basis of serological correlates of protection without efficacy data. The original correlate of protection was established by using a serum bactericidal antibody assay (SBA) with human complement (hSBA), with titers ≥4 predicting protectio...

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Main Authors: Andrews, Nick, Borrow, Ray, Miller, Elizabeth
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC193909/
https://ncbi.nlm.nih.gov/pubmed/12965904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.10.5.780-786.2003
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