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A critical arginine residue mediates cooperativity in the contact interface between transcription factors NFAT and AP-1

The heterologous transcription factors NFAT and AP-1 coordinately regulate cytokine gene expression through cooperative binding to precisely juxtaposed DNA recognition elements. The molecular origins of cooperativity in the binding of NFAT and AP-1 to DNA are poorly understood. Herein we have used y...

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Detalhes bibliográficos
Main Authors: Peterson, Blake R., Sun, Li Jing, Verdine, Gregory L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19386/
https://ncbi.nlm.nih.gov/pubmed/8942992
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