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Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis

As its name suggests, tumor necrosis factor (TNF) is known to induce cytotoxicity in a wide variety of tumor cells and cell lines. However, its use as a chemotherapeutic drug has been limited by its deleterious side effects of systemic shock and widespread inflammatory responses. Some nonsteroidal a...

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Detalhes bibliográficos
Main Authors: Rae, Colin, Langa, Susana, Tucker, Steven J., MacEwan, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937545/
https://ncbi.nlm.nih.gov/pubmed/17646662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701437104
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