Single A326G mutation converts human CYP24A1 from 25-OH-D(3)-24-hydroxylase into -23-hydroxylase, generating 1α,25-(OH)(2)D(3)-26,23-lactone

Studies of 25-hydroxyvitamin D(3)-24-hydroxylase (CYP24A1) have demonstrated that it is a bifunctional enzyme capable of the 24-hydroxylation of 1α,25-(OH)(2)D(3), leading to the excretory form, calcitroic acid, and 23-hydroxylation, culminating in 1α,25-(OH)(2)D(3)-26,23-lactone. The degree to whic...

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Hlavní autoři: Prosser, David E., Kaufmann, Martin, O'Leary, Brendan, Byford, Valarie, Jones, Glenville
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937525/
https://ncbi.nlm.nih.gov/pubmed/17646648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702093104
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