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GATA- and Smad1-Dependent Enhancers in the Smad7 Gene Differentially Interpret Bone Morphogenetic Protein Concentrations

Smad7, an inhibitor of transforming growth factor beta superfamily signaling, is induced by bone morphogenetic protein (BMP) in an inhibitory feedback loop. Here, we identify multiple BMP response elements (BREs) in the Smad7 gene and demonstrate that they function differentially to interpret BMP si...

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Udgivet i:Mol Cell Biol
Principais autores: Benchabane, Hassina, Wrana, Jeffrey L.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12944489/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.18.6646-6661.2003
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