A crucial role for thiol antioxidants in estrogen-deficiency bone loss

The mechanisms through which estrogen prevents bone loss are uncertain. Elsewhere, estrogen exerts beneficial actions by suppression of reactive oxygen species (ROS). ROS stimulate osteoclasts, the cells that resorb bone. Thus, estrogen might prevent bone loss by enhancing oxidant defenses in bone....

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Main Authors: Lean, Jenny M., Davies, Julie T., Fuller, Karen, Jagger, Christopher J., Kirstein, Barrie, Partington, Geoffrey A., Urry, Zoë L., Chambers, Timothy J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC193670/
https://ncbi.nlm.nih.gov/pubmed/12975476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318859
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