Gating currents associated with intramembrane charge displacement in HERG potassium channels

HERG (human ether-a-go-go-related gene) encodes a delayed rectifier K(+) channel vital to normal repolarization of cardiac action potentials. Attenuation of repolarizing K(+) current caused by mutations in HERG or channel block by common medications prolongs ventricular action potentials and increas...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Piper, David R., Varghese, Anthony, Sanguinetti, Michael C., Tristani-Firouzi, Martin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193596/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12928493/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1832721100
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