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DNA vaccine coding for the full-length infectious Kunjin virus RNA protects mice against the New York strain of West Nile virus

A plasmid DNA directing transcription of the infectious full-length RNA genome of Kunjin (KUN) virus in vivo from a mammalian expression promoter was used to vaccinate mice intramuscularly. The KUN viral cDNA encoded in the plasmid contained the mutation in the NS1 protein (Pro-250 to Leu) previousl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hall, Roy A., Nisbet, Debra J., Pham, Kim B., Pyke, Alyssa T., Smith, Greg A., Khromykh, Alexander A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC193583/
https://ncbi.nlm.nih.gov/pubmed/12917491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834270100
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