Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

It has been reported that an insulin 2 gene knockout, when bred onto nonobese diabetic (NOD) mice, accelerates diabetes. We produced insulin 1 gene knockout congenic NOD mice. In contrast to insulin 2, diabetes and insulitis were markedly reduced in insulin 1 knockout mice, with decreased and delaye...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Moriyama, Hiroaki, Abiru, Norio, Paronen, Johanna, Sikora, Kamila, Liu, Edwin, Miao, Dongmei, Devendra, Devasenan, Beilke, Joshua, Gianani, Roberto, Gill, Ron G., Eisenbarth, George S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193569/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12925730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1834450100
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