Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

It has been reported that an insulin 2 gene knockout, when bred onto nonobese diabetic (NOD) mice, accelerates diabetes. We produced insulin 1 gene knockout congenic NOD mice. In contrast to insulin 2, diabetes and insulitis were markedly reduced in insulin 1 knockout mice, with decreased and delaye...

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Detalhes bibliográficos
Main Authors: Moriyama, Hiroaki, Abiru, Norio, Paronen, Johanna, Sikora, Kamila, Liu, Edwin, Miao, Dongmei, Devendra, Devasenan, Beilke, Joshua, Gianani, Roberto, Gill, Ron G., Eisenbarth, George S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193569/
https://ncbi.nlm.nih.gov/pubmed/12925730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834450100
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