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A noncanonical sequence phosphorylated by casein kinase 1 in β-catenin may play a role in casein kinase 1 targeting of important signaling proteins
Protein kinase casein kinase 1 (CK1) phosphorylates Ser-45 of β-catenin, “priming” the subsequent phosphorylation by glycogen synthase-3 of residues 41, 37, and 33. This concerted phosphorylation of β-catenin signals its degradation and prevents its function in triggering cell division. The sequence...
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主要な著者: | , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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National Academy of Sciences
2003
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC193538/ https://ncbi.nlm.nih.gov/pubmed/12925738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1733909100 |
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