A noncanonical sequence phosphorylated by casein kinase 1 in β-catenin may play a role in casein kinase 1 targeting of important signaling proteins

Protein kinase casein kinase 1 (CK1) phosphorylates Ser-45 of β-catenin, “priming” the subsequent phosphorylation by glycogen synthase-3 of residues 41, 37, and 33. This concerted phosphorylation of β-catenin signals its degradation and prevents its function in triggering cell division. The sequence...

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Bibliographische Detailangaben
Hauptverfasser: Marin, Oriano, Bustos, Victor H., Cesaro, Luca, Meggio, Flavio, Pagano, Mario A., Antonelli, Marcelo, Allende, Catherine C., Pinna, Lorenzo A., Allende, Jorge E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC193538/
https://ncbi.nlm.nih.gov/pubmed/12925738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1733909100
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