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Short- and long-range effects of Sonic hedgehog in limb development
The secreted protein Sonic hedgehog (Shh) and its transmembrane receptor Patched (Ptc) control a major signal transduction pathway in early vertebrate limb development. Ligand-free Ptc interacts with the transmembrane protein Smoothened (Smo) and blocks expression of Smo-controlled genes including p...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC193531/ https://ncbi.nlm.nih.gov/pubmed/12930894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1830500100 |
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