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A systematic analysis of the effect of target RNA structure on RNA interference

RNAi efficiency is influenced by local RNA structure of the target sequence. We studied this structure-based resistance in detail by targeting a perfect RNA hairpin and subsequently destabilized its tight structure by mutation, thereby gradually exposing the target sequence. Although the tightest RN...

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Bibliografiske detaljer
Main Authors: Westerhout, Ellen M., Berkhout, Ben
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934999/
https://ncbi.nlm.nih.gov/pubmed/17576691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm437
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