Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease

Kidney podocytes and their foot processes maintain the ultrafiltration barrier and prevent urinary protein loss (proteinuria). Here we show that the GTPase dynamin is essential for podocyte function. During proteinuric kidney disease, induction of cytoplasmic cathepsin L leads to cleavage of dynamin...

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Main Authors: Sever, Sanja, Altintas, Mehmet M., Nankoe, Sharif R., Möller, Clemens C., Ko, David, Wei, Changli, Henderson, Joel, del Re, Elizabetta C., Hsing, Lianne, Erickson, Ann, Cohen, Clemens D., Kretzler, Matthias, Kerjaschki, Dontscho, Rudensky, Alexander, Nikolic, Boris, Reiser, Jochen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934589/
https://ncbi.nlm.nih.gov/pubmed/17671649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32022
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