Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease

Kidney podocytes and their foot processes maintain the ultrafiltration barrier and prevent urinary protein loss (proteinuria). Here we show that the GTPase dynamin is essential for podocyte function. During proteinuric kidney disease, induction of cytoplasmic cathepsin L leads to cleavage of dynamin...

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Main Authors: Sever, Sanja, Altintas, Mehmet M., Nankoe, Sharif R., Möller, Clemens C., Ko, David, Wei, Changli, Henderson, Joel, del Re, Elizabetta C., Hsing, Lianne, Erickson, Ann, Cohen, Clemens D., Kretzler, Matthias, Kerjaschki, Dontscho, Rudensky, Alexander, Nikolic, Boris, Reiser, Jochen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934589/
https://ncbi.nlm.nih.gov/pubmed/17671649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32022
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