Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease

Kidney podocytes and their foot processes maintain the ultrafiltration barrier and prevent urinary protein loss (proteinuria). Here we show that the GTPase dynamin is essential for podocyte function. During proteinuric kidney disease, induction of cytoplasmic cathepsin L leads to cleavage of dynamin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sever, Sanja, Altintas, Mehmet M., Nankoe, Sharif R., Möller, Clemens C., Ko, David, Wei, Changli, Henderson, Joel, del Re, Elizabetta C., Hsing, Lianne, Erickson, Ann, Cohen, Clemens D., Kretzler, Matthias, Kerjaschki, Dontscho, Rudensky, Alexander, Nikolic, Boris, Reiser, Jochen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2007
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934589/
https://ncbi.nlm.nih.gov/pubmed/17671649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32022
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