Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease

Kidney podocytes and their foot processes maintain the ultrafiltration barrier and prevent urinary protein loss (proteinuria). Here we show that the GTPase dynamin is essential for podocyte function. During proteinuric kidney disease, induction of cytoplasmic cathepsin L leads to cleavage of dynamin...

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Hlavní autoři: Sever, Sanja, Altintas, Mehmet M., Nankoe, Sharif R., Möller, Clemens C., Ko, David, Wei, Changli, Henderson, Joel, del Re, Elizabetta C., Hsing, Lianne, Erickson, Ann, Cohen, Clemens D., Kretzler, Matthias, Kerjaschki, Dontscho, Rudensky, Alexander, Nikolic, Boris, Reiser, Jochen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2007
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934589/
https://ncbi.nlm.nih.gov/pubmed/17671649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32022
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