Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability

Two major protein degradation systems exist in cells, the ubiquitin proteasome system and the autophagy machinery. Here, we investigated the functional relationship of the two systems and the underlying mechanisms. Proteasome inhibition activated autophagy, suggesting that the two are functionally c...

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Detalhes bibliográficos
Main Authors: Ding, Wen-Xing, Ni, Hong-Min, Gao, Wentao, Yoshimori, Tamotsu, Stolz, Donna B., Ron, David, Yin, Xiao-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934546/
https://ncbi.nlm.nih.gov/pubmed/17620365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070188
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