A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal

Adenoviruses are attractive vectors for the delivery of foreign genes into mammalian cells for gene therapy. However, current vectors retain many viral genes that, when expressed at low levels, contribute to the induction of a host immune response against transduced cells. We have developed a helper...

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Bibliografiske detaljer
Main Authors: Parks, Robin J., Chen, Liane, Anton, Martina, Sankar, Uma, Rudnicki, Michael A., Graham, Frank L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC19345/
https://ncbi.nlm.nih.gov/pubmed/8942974
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