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Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase

Metronidazole, a 5-nitroimidazole drug, has been the gold standard for several decades in the treatment of infections with microaerophilic protist parasites, including Entamoeba histolytica. For activation, the drug must be chemically reduced, but little is known about the targets of the active meta...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Leitsch, David, Kolarich, Daniel, Wilson, Iain B. H, Altmann, Friedrich, Duchêne, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933457/
https://ncbi.nlm.nih.gov/pubmed/17676992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050211
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