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BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges
Mutations in BLM cause Bloom's syndrome, a disorder associated with cancer predisposition and chromosomal instability. We investigated whether BLM plays a role in ensuring the faithful chromosome segregation in human cells. We show that BLM-defective cells display a higher frequency of anaphase...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1933408/ https://ncbi.nlm.nih.gov/pubmed/17599064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601777 |
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