DNA Immunization Using Highly Conserved Murine Cytomegalovirus Genes Encoding Homologs of Human Cytomegalovirus UL54 (DNA Polymerase) and UL105 (Helicase) Elicits Strong CD8 T-Cell Responses and Is Protective against Systemic Challenge

Human cytomegalovirus (HCMV) establishes a lifelong infection with the potential for reinfection or viral transmission even in the presence of strong and diverse CD8 T-lymphocyte responses. This suggests that the CMVs skew the host T-cell response in order to favor viral persistence. In this study,...

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Bibliographic Details
Main Authors: Morello, Christopher S., Kelley, Laura A., Munks, Michael W., Hill, Ann B., Spector, Deborah H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933361/
https://ncbi.nlm.nih.gov/pubmed/17507492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00633-07
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