In Vivo Study of the HC-TN Strain of Hepatitis C Virus Recovered from a Patient with Fulminant Hepatitis: RNA Transcripts of a Molecular Clone (pHC-TN) Are Infectious in Chimpanzees but Not in Huh7.5 Cells

Both viral and host factors are thought to influence the pathogenesis of hepatitis C virus (HCV) infection. We studied strain HC-TN (genotype 1a), which caused fulminant hepatic failure in a patient and, subsequently, severe hepatitis in a chimpanzee (CH1422), to analyze the relationship between dis...

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Detalhes bibliográficos
Main Authors: Sakai, Akito, Takikawa, Shingo, Thimme, Robert, Meunier, Jean-Christophe, Spangenberg, Hans Christian, Govindarajan, Sugantha, Farci, Patrizia, Emerson, Suzanne U., Chisari, Francis V., Purcell, Robert H., Bukh, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933310/
https://ncbi.nlm.nih.gov/pubmed/17409145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01774-06
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