Diverse Herpes Simplex Virus Type 1 Thymidine Kinase Mutants in Individual Human Neurons and Ganglia

Mutations in the thymidine kinase gene (tk) of herpes simplex virus type 1 (HSV-1) explain most cases of virus resistance to acyclovir (ACV) treatment. Mucocutaneous lesions of patients with ACV resistance contain mixed populations of tk mutant and wild-type virus. However, it is unknown whether hum...

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Autores principales: Wang, Kening, Mahalingam, Gowtham, Hoover, Susan E., Mont, Erik K., Holland, Steven M., Cohen, Jeffrey I., Straus, Stephen E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933309/
https://ncbi.nlm.nih.gov/pubmed/17459924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00166-07
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