Molecular Basis for Preferential Protective Efficacy of Antibodies Directed to the Poorly Acetylated Form of Staphylococcal Poly-N-Acetyl-β-(1-6)-Glucosamine

Poly-N-acetyl-glucosamine (PNAG) is a staphylococcal surface polysaccharide influencing biofilm formation that is also under investigation for its vaccine potential. Antibodies that bind to PNAG with either low (<15%) or high (>90%) levels of acetate are superior at opsonic and protective acti...

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Detalhes bibliográficos
Main Authors: Cerca, Nuno, Jefferson, Kimberly K., Maira-Litrán, Tomas, Pier, Danielle B., Kelly-Quintos, Casie, Goldmann, Donald A., Azeredo, Joana, Pier, Gerald B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932961/
https://ncbi.nlm.nih.gov/pubmed/17470540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00078-07
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