Transcutaneous Immunization with Clostridium difficile Toxoid A Induces Systemic and Mucosal Immune Responses and Toxin A-Neutralizing Antibodies in Mice

Clostridium difficile is the leading cause of nosocomial infectious diarrhea. C. difficile produces two toxins (A and B), and systemic and mucosal anti-toxin A antibodies prevent or limit C. difficile-associated diarrhea. To evaluate whether transcutaneous immunization with formalin-treated C. diffi...

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Autors principals: Ghose, Chandrabali, Kalsy, Anuj, Sheikh, Alaullah, Rollenhagen, Julianne, John, Manohar, Young, John, Rollins, Sean M., Qadri, Firdausi, Calderwood, Stephen B., Kelly, Ciaran P., Ryan, Edward T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
Matèries:
Microbial Immunity and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932889/
https://ncbi.nlm.nih.gov/pubmed/17371854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00127-07
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