BRCA1 regulates p53-dependent gene expression

Mutations in BRCA1 are present in 45% of families that segregate with susceptibility for breast cancer and in 80–90% of families with both breast and ovarian cancer. Here we report that BRCA1 stimulates artificial and genomic promoter constructs containing p53-responsive elements. This activity of B...

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Hlavní autoři: Ouchi, Toru, Monteiro, Alvaro N. A., August, Avery, Aaronson, Stuart A., Hanafusa, Hidesaburo
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC19327/
https://ncbi.nlm.nih.gov/pubmed/9482880
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