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Targeting Effector Memory T Cells with the Small Molecule Kv1.3 Blocker PAP-1 Suppresses Allergic Contact Dermatitis

The voltage-gated potassium channel Kv1.3 has been recently identified as a molecular target that allows for selective pharmacological suppression of effector memory T (T(EM)) cells without affecting the function of naïve and central memory T cells. We here investigated whether PAP-1, a small molecu...

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Bibliografski detalji
Glavni autori: Azam, Philippe, Sankaranarayanan, Ananthakrishnan, Homerick, Daniel, Griffey, Stephen, Wulff, Heike
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1929164/
https://ncbi.nlm.nih.gov/pubmed/17273162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.jid.5700717
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