Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease
Restriction endonucleases such as EcoRI bind and cleave DNA with great specificity and represent a paradigm for protein–DNA interactions and molecular recognition. Using osmotic pressure to induce water release, we demonstrate the participation of bound waters in the sequence discrimination of subst...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19290/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9482860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.5.2186 |
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