A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential.

Recently, a number of novel quinolones with potent activity against topoisomerase II and eukaryotic cells have been described. Many of these compounds contain aromatic substituents in their C-7 ring positions. To determine whether pyrimido[1,6-a]benzimidazoles, a class of drugs modeled on quinolones...

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Main Authors: Corbett, A H, Guerry, P, Pflieger, P, Osheroff, N
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC192751/
https://ncbi.nlm.nih.gov/pubmed/8109923
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