Ligand-induced overexpression of a constitutively active β(2)-adrenergic receptor: Pharmacological creation of a phenotype in transgenic mice

Transgenic overexpression (40- to 100-fold) of the wild-type human β(2)-adrenergic receptor in the hearts of mice leads to a marked increase in cardiac contractility, which is apparently due to the low level of spontaneous (i.e., agonist-independent) activity inherent in the receptor. Here we report...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Samama, Philippe, Bond, Richard A., Rockman, Howard A., Milano, Carmelo A., Lefkowitz, Robert J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19258/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8990174/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.1.137
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