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Ligand-induced overexpression of a constitutively active β(2)-adrenergic receptor: Pharmacological creation of a phenotype in transgenic mice
Transgenic overexpression (40- to 100-fold) of the wild-type human β(2)-adrenergic receptor in the hearts of mice leads to a marked increase in cardiac contractility, which is apparently due to the low level of spontaneous (i.e., agonist-independent) activity inherent in the receptor. Here we report...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences of the USA
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC19258/ https://ncbi.nlm.nih.gov/pubmed/8990174 |
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