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Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA

Peptide nucleic acid (PNA) is a DNA mimic that has shown considerable promise as a lead compound for developing gene therapeutic drugs. We report that PNAs targeted to functional and accessible sites in ribosomal RNA can inhibit translation in an Escherichia coli cell-free transcription/translation...

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Bibliografske podrobnosti
Main Authors: Good, Liam, Nielsen, Peter E.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC19253/
https://ncbi.nlm.nih.gov/pubmed/9482840
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