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Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)–mediated inhibition of caspase 9

During apoptosis, the initiator caspase 9 is activated at the apoptosome after which it activates the executioner caspases 3 and 7 by proteolysis. During this process, caspase 9 is cleaved by caspase 3 at Asp(330), and it is often inferred that this proteolytic event represents a feedback amplificat...

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Библиографические подробности
Главные авторы: Denault, Jean-Bernard, Eckelman, Brendan P., Shin, Hwain, Pop, Cristina, Salvesen, Guy S.
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2007
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1925235/
https://ncbi.nlm.nih.gov/pubmed/17437405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070288
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