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Using 5′-PTMs to repair mutant β-globin transcripts
Trans-splicing has been used to repair mutant RNA transcripts via competition for the spliceosome using pre-trans-splicing molecules, or “PTMs.” Previous studies have demonstrated that functional PTMs can be designed for either 3′- or 5′-exon replacement, with a vast majority of the work to date foc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1924905/ https://ncbi.nlm.nih.gov/pubmed/17556711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.525607 |
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