A Cytosolic Splice Variant of Cab45 Interacts with Munc18b and Impacts on Amylase Secretion by Pancreatic Acini

We identified in a yeast two-hybrid screen the EF-hand Ca(2+)-binding protein Cab45 as an interaction partner of Munc18b. Although the full-length Cab45 resides in Golgi lumen, we characterize a cytosolic splice variant, Cab45b, expressed in pancreatic acini. Cab45b is shown to bind (45)Ca(2+), and,...

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Autors principals: Lam, Patrick P.L., Hyvärinen, Kati, Kauppi, Maria, Cosen-Binker, Laura, Laitinen, Saara, Keränen, Sirkka, Gaisano, Herbert Y., Olkkonen, Vesa M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2007
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924827/
https://ncbi.nlm.nih.gov/pubmed/17442889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-10-0950
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