Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of β cells

The pathogenesis of type 1 diabetes (T1D) involves the immune-mediated destruction of insulin-producing β cells in the pancreatic islets of Langerhans. Genetic analysis of families with a high incidence of T1D and nonobese diabetic (NOD) mice, a prototypical model of the disorder, uncovered multiple...

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Detalhes bibliográficos
Main Authors: Enzler, Thomas, Gillessen, Silke, Dougan, Michael, Allison, James P., Neuberg, Donna, Oble, Darryl A., Mihm, Martin, Dranoff, Glenn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924767/
https://ncbi.nlm.nih.gov/pubmed/17483299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-08-043786
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