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Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis

The pathogenicity of mycobacteria such as Mycobacterium tuberculosis is closely associated with their capacity to survive within host macrophages. A crucial virulence factor for intracellular mycobacterial survival is protein kinase G (PknG), a eukaryotic-like serine/threonine protein kinase express...

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Main Authors: Scherr, Nicole, Honnappa, Srinivas, Kunz, Gabriele, Mueller, Philipp, Jayachandran, Rajesh, Winkler, Fritz, Pieters, Jean, Steinmetz, Michel O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924570/
https://ncbi.nlm.nih.gov/pubmed/17616581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702842104
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